Table 3.

Cox regression for overall survival in patients receiving best supportive care only after diagnosis of metastatic disease.

	Events	Median OS (months)	Univariable regression		Multivariable regressiona,b
			HR (95% CI)	p value	HR (95% CI)	p value
Synchronous	1857	2.0	Ref		Ref
Early metachronous	156	1.5	1.33 (1.13–1.56)	<0.001	1.41 (1.18–1.68)	<0.001
Late metachronous	364	2.2	0.90 (0.81–1.00)	0.07	1.02 (0.89–1.15)	0.81

CI, confidence interval; HR, hazard ratio; OS, overall survival.

^aAdjusted for gender, age, number of comorbidities, tumor location at primary diagnosis, cT stage at primary diagnosis, cN stage at primary diagnosis, Lauren’s classification at primary diagnosis, tumor differentiation at primary diagnosis, number of metastatic sites and location of metastases (distant lymph nodes, liver metastases, lung, bone, peritoneal, and other).

^bPerformance status did not meet the proportional hazard assumptions and the model was stratified for these covariates.