Table 1. Cohort characteristics at baseline.

Characteristic		n	%a
Age, years	Median (IQR)	52	36–66
	Mean (SD)	52	19
Age group, years	18–39	210 047	29.9
	40–59	241 831	34.4
	60–79	194 168	27.6
	≥80	56 219	8.0
Sex	Male	328 712	46.8
	Female	373 553	53.2
Socioeconomic status (IMD quintile)	1 (most deprived)	102 796	14.6
	2	126 069	18.0
	3	132 262	18.8
	4	146 622	20.9
	5 (least deprived)	186 284	26.5
	Missing	8232	1.2
Ethnic group	British and Mixed British (Irish, Other, or White)	427 019	60.8
	Mixed (White and Asian, White and Black African, White and Black Caribbean, or Other Mixed)	3863	0.6
	Indian, Bangladeshi, Pakistani, or Other Asian	13 180	1.9
	African, Caribbean, or Other Black	5251	0.7
	Other	7236	1.0
	Missing	245 716	35.0
Long-term condition diagnosed at the point of baseline	Chronic kidney disease	36 059	5.1
	CVD (ischaemic heart disease, cerebrovascular disease, and peripheral cardiovascular disease)	52 985	7.5
	Heart failure	12 799	1.8
	Diabetes	62 767	8.9
	Hypertension	150 458	21.4
	Osteoarthritis	95 294	13.6
	Rheumatoid arthritis	6723	1.0
Prescribed at baseline	NSAID	19 364	2.8

^aUnless otherwise stated. CVD = cardiovascular disease. CVD = cardiovascular disease. IQR = interquartile range. IMD = Index of Multiple Deprivation. NSAID = non-steroidal anti-inflammatory drug. SD = standard deviation.