Table 2. Knowledge of HPV as risk factor for OPC and epidemiological trends of OPC incidence among 207 GPs in the Netherlands (2020).
| Total, n (%) | Sex, n (%) | Years after graduation as GP, n (%) | Self-rated knowledge of OPC, n (%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female | Male | P value | <2a | 2–5 | 5–10 | 10–20 | >20 | P value | Poor | Sufficient | Good | P value | |||
| Were you aware of the link between HPV and OPC before today? | Yes | 149 (72.0%) | 80 (74.8%) | 69 (69.0%) | 0.273 | 14 (87.5%) | 14 (77.8%) | 31 (79.5%) | 39 (66.1%) | 51 (68.0%) | 0.267 | 29 (59.2%) | 112 (75.7%) | 8 (80.0%) | 0.216 |
| No | 49 (23.7%) | 21 (19.6%) | 28 (28.0%) | 2 (12.5%) | 2 (11.1%) | 7 (17.9%) | 16 (27.1%) | 22 (29.3) | 17 (34.7%) | 30 (20.3%) | 2 (20.0%) | ||||
| Not sure | 9 (4.3%) | 6 (5.6%) | 3 (3.0%) | 0 (0.0%) | 2 (11.1%) | 1 (2.6%) | 4 (6.8%) | 2 (2.7%) | 3 (6.1%) | 6 (4.1%) | 0 (0.0%) | ||||
| Total | 207 (100%) | 107 (100%) | 100 (100%) | 16 (100%) | 18 (100%) | 39 (100%) | 59 (100%) | 75 (100%) | 49 (100%) | 148 (100%) | 10 (100%) | ||||
| Over the past two decades, HPV- associated OPC rates have: | Increased | 158 (76.3%) | 80 (74.8%) | 78 (78.0%) | 0.135 | 10 (62.5%) | 11 (61.1%) | 35 (89.7%) | 42 (71.2%) | 60 (80.0%) | 0.020b | 36 (73.5%) | 114 (77.0%) | 8 (80.0%) | 0.664 |
| Decreased | 6 (2.9%) | 2 (1.9%) | 4 (4.0%) | 2 (12.5%) | 2 (11.1%) | 0 (0.0%) | 0 (0.0%) | 2 (2.7%) | 1 (2.0%) | 5 (3.4%) | 0 (0.0%) | ||||
| Stayed the same | 8 (3.9%) | 7 (6.5%) | 1 (1.0%) | 2 (12.5%) | 1 (5.6%) | 2 (5.1%) | 2 (3.4%) | 1 (1.3%) | 4 (8.2%) | 4 (2.7%) | 0 (0.0%) | ||||
| Not sure | 35 (16.9%) | 18 (16.8%) | 17 (17.0%) | 2 (12.5%) | 4 (22.2%) | 2 (5.1%) | 15 (25.4%) | 12 (16.0%) | 8 (16.3%) | 25 (16.9%) | 2 (20.0%) | ||||
| Total | 207 (100%) | 107 (100%) | 100 (100%) | 16 (100%) | 18 (100%) | 39 (100%) | 59 (100%) | 75 (100%) | 49 (100%) | 148 (100%) | 10 (100%) | ||||
| Over the past two decades. smoking- associated OPC rates have: | Increased | 96 (46.4%) | 58 (54.2%) | 38 (38.0%) | 0.021 | 7 (43.8%) | 10 (55.6%) | 19 (48.7%) | 26 (44.1%) | 34 (45.3%) | 0.354 | 26 (53.1%) | 64 (43.2%) | 6 (60.0%) | 0.219 |
| Decreased | 41 (19.8%) | 15 (14.0%) | 26 (26.0%) | 4 (25.0%) | 4 (22.2%) | 8 (20.5%) | 13 (22.0%) | 12 (16.0%) | 5 (10.2%) | 34 (23.0%) | 2 (20.0%) | ||||
| Stayed the same | 42 (20.3%) | 17 (15.9%) | 25 (25.0%) | 4 (25.0%) | 4 (22.2%) | 4 (10.3%) | 10 (16.9%) | 20 (26.7%) | 9 (18.4%) | 31 (20.9%) | 2 (20.0%) | ||||
| Not sure | 28 (13.5%) | 17 (15.9%) | 11 (11.0%) | 1 (6.3%) | 0 (0.0%) | 8 (20.5%) | 10 (16.9%) | 9 (12.0%) | 9 (18.4%) | 19 (12.8%) | 0 (0.0%) | ||||
| Total | 207 (100%) | 107 (100%) | 100 (100%) | 16 (100%) | 18 (100%) | 39 (100%) | 59 (100%) | 75 (100%) | 49 (100%) | 148 (100%) | 10 (100%) | ||||
aAlso includes GPs still in training. bNo statistically significant trend observed with the extended Mantel-Haenszel test. P values were calculated with χ2 tests or likelihood ratio tests. HPV = human papillomavirus. OPC = oropharyngeal cancer.