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. Author manuscript; available in PMC: 2022 Mar 28.
Published in final edited form as: Bioessays. 2021 Nov 10;44(1):e2100201. doi: 10.1002/bies.202100201

FIGURE 2.

FIGURE 2

Centromeric transcription may be regulated at the levels of DNA sequences and histone tail modifications. Top panel: Centromeres tend to adopt non-B form DNA conformations such as stem loop, which might allow centromeric transcription to be less dependent on some transcriptional initiation factors. Bottom panel: The histone modification H3K4me2 renders the centromeric chromatin “transcription-permissive,” which may be required for centromeric transcription. Centromere proteins including CENP-B might be involved in the regulation of H3K4me2. The lysine methyltransferase(s) (KMT) responsible for H3K4me2 at centromeres is yet to be identified.