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. 2021 Aug 4;19(3):343–357. doi: 10.20892/j.issn.2095-3941.2020.0661

Figure 6.

Figure 6

METTL3 maintained CCA cell stemness in vivo and facilitated tumor progression. (A) Representative images for the tumors of implantations of the shRNA-transformed SK-Cha-1 cells into the flanks of 6-week-old male nude mice. (B) The knockdown of METTL3 inhibited malignant proliferation of SK-Cha-1 cells and tumor size and weight in vivo. Error bars denote ± SEM (6 mice per group; *P < 0.05). (C) Immunoblots showing the expression levels of CTNNB1, CD133, and METTL3 in tumors from METTL3 knockdown mice.