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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: Chem Rev. 2021 Dec 14;122(3):3336–3413. doi: 10.1021/acs.chemrev.1c00729

Figure 13.

Figure 13.

Fluorescent reporter probes for TPase-mediated PG cross-linking. (A) Fluorescent stem pentapeptide mimics resembling the donor strand (FSPPM) are proposed to incorporate via D,D-TPase activity as shown for S. aureus PG; FSPPMs could theoretically also incorporate via L,D-TPase activity if the terminal D-Ala were cleaved first by a CPase. (B) Fluorescent stem tetrapeptide mimics resembling the donor strand (FSTPM), which lack the terminal D-Ala of FSPPMs, are proposed to incorporate exclusively via L,D-TPase activity.