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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: Chem Rev. 2021 Dec 14;122(3):3336–3413. doi: 10.1021/acs.chemrev.1c00729

Figure 21.

Figure 21.

Fucose-based chemical reporters for metabolic labeling of E. coli O86 LPS O-antigen. (A) Structure of the E. coli O86 LPS O-antigen. (B) Fucose salvage pathway from Bacteroides engineered into E. coli O86. The bifunctional enzyme Fkp possesses both fucose kinase and GDP fucose pyrophosphorylase activity. Subsequent polymerization of the O-antigen subunit and assembly into mature LPS is shown in Figure 18. (B) Representative fucose analogues as chemical reporters for the E. coli O86 LPS O-antigen.