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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: Chem Rev. 2021 Dec 14;122(3):3336–3413. doi: 10.1021/acs.chemrev.1c00729

Figure 23.

Figure 23.

AltdiNAc-based chemical reporters for labeling pseudaminic acid residues of LPS O-antigen. (A) Structure of a pseudaminic acid-containing LPS O-antigen from P. aeruginosa. FucNAc, N-acetylfucosamine; Pse5Ac7Fo, pseudaminic acid derivative with 5-acetamido and 7-formamido groups; Xyl, xylose. (B) Biosynthesis of O-antigen precursor CMP-Pse, which arises from an AltdiNAc intermediate. Subsequent polymerization of the O-antigen subunit and assembly into mature LPS is shown in Figure 18. (C) Structures of azide-modified AltdiNAc chemical reporters.