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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: Chem Rev. 2021 Dec 14;122(3):3336–3413. doi: 10.1021/acs.chemrev.1c00729

Figure 28.

Figure 28.

(A) MandiNAc-based chemical reporters for labeling legionaminic acid residues of C. jejuni flagellin glycoproteins. See Figure 22B for a relevant biosynthetic pathway and the structure of MandiNAc. (B) Imaging of C. jejuni flagellin glycans using compound 83. C. jejuni was incubated in the presence of 83, fixed, subjected to SPAAC with cyclooctyne-PEG-biotin, stained with streptavidin-488, and imaged by fluorescence microscopy. A secondary dye (red) stained the body of the bacterium. Scale bar, 1 μm. Reproduced from ref 193.