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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: Chem Rev. 2021 Dec 14;122(3):3336–3413. doi: 10.1021/acs.chemrev.1c00729

Figure 6.

Figure 6.

PG precursor derivatives designed to label the PG stem peptide based on (A) Park’s nucleotide and (B) Lipid I and II. (C) Convergent chemoenzymatic synthesis of PG precursor derivatives 1 and 2. AAs, amino acid building blocks; DIEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; HBTU, (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; NHS, N-hydroxysuccinimidyl; NADPH, nicotinamide adenine dinucleotide phosphate hydride; PEP, phosphoenolpyruvate; UDP, uridine diphosphate.