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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: Chem Rev. 2021 Dec 14;122(3):3336–3413. doi: 10.1021/acs.chemrev.1c00729

Figure 7.

Figure 7.

D-amino acid derivatives targeting the PG stem peptide. (A) Metabolic incorporation of unnatural D-amino acid derivatives (modified with an unnatural R group) is proposed to predominantly occur through periplasmic TPase-mediated PG remodeling. Incorporation by PBP D,D-TPases to install the probe at the 5-position of the peptide is shown; incorporation by L,D-TPases to install the probe at the 4-position can also occur. Smaller D-amino acid derivatives may additionally incorporate into PG via an intracellular route. (B and C) Structures of D-amino acid derivatives bearing selectively reactive functional groups (B) and fluorophores (C).