TABLE 3.
Nucleotide polymorphisms and genotype counts
| Locus | Polymorphic nucleotide position(s)a | Genotype (no. of strains)b |
|---|---|---|
| C15F2 | 174 | AA (21), AG (44), GG (19) |
| 207 (A, G)c | ||
| C12F10 | 218 | GG (68), GT (15), TT (1) |
| C2F7 | 50 (G, T) | |
| 68 (A, G) | ||
| 95 | CC (16), CT (2), TT (66)*** | |
| 119 (A, G) | ||
| 245 (C, T) | ||
| 260 (A, G) | ||
| C2F10 | 151 | AA (25), AG (14), GG (45)*** |
| CHS2 | 2028 (C, T) | |
| 2055 | CC (81), CT (0), TT (3)*** | |
| 2153 (A, G) | ||
| C2F17 | 206 | CC (46), CT (25), TT (13)** |
| 214 (A, G) | ||
| 257 (A, G) | ||
| ARG4 | 1789 | AA (20), CC (1), TT (18), |
| AC (38), AT (6), CT (1)*** | ||
| 1864 (C, T) | ||
| CPH1 | 1204 | AA (6), AT (61), TT (17)*** |
| 1213 (A, G) | ||
| 1258 (C, T) | ||
| 1261 (A, G) | ||
| 1616 (C, G) | ||
| 1687 (A, C) | ||
| 1771 (A, G) | ||
| FAS2 | 4671 (A, G) | |
| 4773 | AA (8), AG (35), GG (41) | |
| 4869 (A, T) | ||
| 4884 (C, T) | ||
| 4917 (C, T) | ||
| 4953 (C, T) | ||
| GCN1 | 145 | AA (3), AC (15), CC (66) |
| 235 (A, G) | ||
| PDE1 | 986 (A, G) | |
| 991 (A, G) | ||
| 1046 | AA (16), AG (51), GG (17) | |
| 1088 (A, G) | ||
| LEU2 | 96 (C, T) | |
| 190 | CC (31), CT (33), TT (20) | |
| CZF1 | 728 | AA (76), AG (7), GG (1) |
| HEX1 | 906 (A, G, T) | |
| 1915 (A, G) | ||
| 2063 (C, T) | ||
| 2070 (C, T) | ||
| 2080 (C, T) | ||
| 2089 | CC (54), CT (6), TT (24)*** | |
| 2109 (A, G) | ||
| 2135 (A, G) | ||
| 2179 (A, C) | ||
| MNS1 | 362 | CC (9), CT (12), TT (63)*** |
| ERG7 | 294 (indel) (AAAGTG)d | ++ (11), +− (46), −− (27) |
Polymorphic positions are relative to the accessioned sequences.
Diploid genotypes are followed by number of strains in parentheses. In all cases, the total number of C. albicans strains assayed was 84. **, counts significantly different from Hardy-Weinberg expectation at P < 0.05; ***, counts significantly different from Hardy-Weinberg expectation at P < 0.001.
Polymorphic positions whose alternative nucleotides are given in parentheses were found in the initial sequencing of representatives of each allelic class identified by SSCPs; these positions were not assayed in the complete set of 84 strains of C. albicans.
This polymorphism is for presence, indicated as a plus in the genotypes, or, for absence, indicated as a minus in the genotypes of the 6-nucleotide sequence shown in parentheses.