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. 2022 Mar 24;13:553–575. doi: 10.18632/oncotarget.28220

Table 1. The establishment rate of PDX models derived from different ovarian cancer subtypes.

Tumor type Mice strain Implantation site Engraftment rate (%) No of PDXs References
High grade serous

NSG

NSG, NOD/SCID

nude

NSG

NSG, NOD/SCID

nude

SCID/Beige

nude

nude

SQ, IB

SQ, IB

IP

FT/ovary

MFP

SQ, IP, IB

IP

interscapular fat pad

SRC

83

>90

31

>90

>90

ND

82

54

49

12

9

29

40

38

15

111

28

20

[27]

[73]

[80]

[85]

[79]

[74]

[75]

[86]

[77]

Low grade serous SCID/Beige IP 100 1 [29]
Mucinous

nude

nude

SCID/Beige

nude

SQ

SQ, IP, IB

IP

interscapular fat pad

100

ND

50

50

2

2

2

1

[117]

[74]

[75]

[86]

Endometrioid

nude

SCID/Beige

SQ

IP

100

64

5

11

[74]

[75]

Clear cell

nude

nude

SCID/Beige

nude

SRC

SQ, IP, IB

IP

interscapular fat pad

50

ND

90

100

2

2

10

1

[77]

[74]

[75]

[86]

Abbreviations: IB: intrabursal; IP: intraperitoneal; FT: fallopian tube; MFP: mammary fat pad; SRC: subrenal capsule; SQ: subcutaneous; ND: not determined.