Table 1. The establishment rate of PDX models derived from different ovarian cancer subtypes.
Tumor type | Mice strain | Implantation site | Engraftment rate (%) | No of PDXs | References |
---|---|---|---|---|---|
High grade serous |
NSG NSG, NOD/SCID nude NSG NSG, NOD/SCID nude SCID/Beige nude nude |
SQ, IB SQ, IB IP FT/ovary MFP SQ, IP, IB IP interscapular fat pad SRC |
83 >90 31 >90 >90 ND 82 54 49 |
12 9 29 40 38 15 111 28 20 |
[27] [73] [80] [85] [79] [74] [75] [86] [77] |
Low grade serous | SCID/Beige | IP | 100 | 1 | [29] |
Mucinous |
nude nude SCID/Beige nude |
SQ SQ, IP, IB IP interscapular fat pad |
100 ND 50 50 |
2 2 2 1 |
[117] [74] [75] [86] |
Endometrioid |
nude SCID/Beige |
SQ IP |
100 64 |
5 11 |
[74] [75] |
Clear cell |
nude nude SCID/Beige nude |
SRC SQ, IP, IB IP interscapular fat pad |
50 ND 90 100 |
2 2 10 1 |
[77] [74] [75] [86] |
Abbreviations: IB: intrabursal; IP: intraperitoneal; FT: fallopian tube; MFP: mammary fat pad; SRC: subrenal capsule; SQ: subcutaneous; ND: not determined.