Table 6.
Technical characteristics of smart insulin pens.
| Pen device (year of introduction) | Company | Insulin producing company/insulin compatibilities | Cartridge volume and insulin concentration | Dose range (dose increment) | Monitors active insulin on board/bolus dose calculator | Reports to download/connects with company app on smartphones | Special characteristics | Battery lifetime/application service | |
|---|---|---|---|---|---|---|---|---|---|
| InPen™ (2017) (123, 143) | Companion Medical | Lilly | Humalog® | 3 ml (100 IU/ml) | 0.5–30 units (0.5 unit) | Yes | Yes | Integrates with CGM, insulin injection reminder, temperature sensor | 1 year/ Android, Apple |
| Novo Nordisk | NovoLog® | ||||||||
| Fiasp® | |||||||||
| ESYSTA® BT pen (144) | Emperra | Novo Nordisk | NovoRapid® | 3 ml (100 IU/ml) | 1–60 units (1 unit) | Yes | Yes | Stores 1,000 records, displays of the last insulin dose | 6 months, replaceable/ Android, Apple |
| NovoMix® 30 | |||||||||
| Levemir® | |||||||||
| Actrapid® | |||||||||
| Actraphane® 30/-50 | |||||||||
| Protaphane® | |||||||||
| Sanofi-Aventis | Lantus® | ||||||||
| Apidra® | |||||||||
| Insuman® Rapid | |||||||||
| Insuman® Comb 15/-25/-50 | |||||||||
| Insuman® Basal | |||||||||
| Lilly | Huminsulin® Normal | ||||||||
| Huminsulin® Profil III | |||||||||
| Huminsulin® Basal (NPH) | |||||||||
| Humalog® | |||||||||
| Humalog® Mix 25/-50 | |||||||||
| Abasaglar® | |||||||||
| Berlin-Chemie | Berlinsulin® H Normal | ||||||||
| Berlinsulin® H 30/70 | |||||||||
| Berlinsulin® H Basal | |||||||||
| Liprolog® Mix 25/-50 Pen | |||||||||
| Liprolog® | |||||||||
| B. Braun | Insulin B. Braun Rapid® | ||||||||
| Insulin B. Braun Comb® | |||||||||
| Insulin B. Braun Basal® | |||||||||
| Pendiq 2.0 (145) | Pendiq | Novo Nordisk | NovoRapid® | 3 ml (100 IU/ml) | 0.5–60 units (0.1 unit) |
No | Yes | Low battery/insulin level alarms, data transmit to a computer with USB cable, stores 1,000 records | Rechargeable with USB charger/ Android, Apple |
| Fiasp® | |||||||||
| NovoLog® | |||||||||
| Lilly | Humalog® | ||||||||
| Sanofi-Aventis | Apidra® | ||||||||
| Lispro® | |||||||||
| Berlin-Chemie | Liprolog® | ||||||||
| NovoPen® 6 (2019) (146) | Novo Nordisk | Novo Nordisk | NovoRapid® | 3 ml (100 IU/ml) | 1–60 units (1 unit) | Yes | Yes | Dose memory, uses NFC to transfer data | 4 to 5 years/ Android, Apple |
| NovoLog® | |||||||||
| Actrapid® | |||||||||
| Fiasp® | |||||||||
| Levemir® | |||||||||
| Tresiba® | |||||||||
NFC, near-field communication.