TABLE 5.

Univariate analysis of predictors of the number of small vascular disease (SVD) markers ≥ 3.

	Number of SVD markers ≤ 2 n = 539	Number of SVD markers ≥ 3 n = 369	P	CI
Age (≥70), n (%)			<0.001	4.802	8.692
<69, n (%)	371 (68.8%)	94 (25.5%)
≥70, n (%)	168 (31.2%)	275 (74.5%)
Sex, n (%)
Female, n (%)	255 (47.3%)	176 (47.7%)	0.909	0.779	1.324
Male, n (%)	284 (52.7%)	193 (52.3%)
Smoking, n (%)	135 (25.1%)	69 (18.8%)	0.026	0.499	0.958
Drinking, n (%)	96 (18.0%)	40 (10.9%)	0.004	0.376	0.83
Previous history
Atrial fibrillation, n (%)	16 (3.0%)	24 (6.5%)	0.011	1.191	4.343
Diabetes mellitus, n (%)	179 (33.2%)	149 (40.4%)	0.027	1.035	1.792
Previous stroke, n (%)	19 (3.5%)	26 (7.0%)	0.016	1.131	3.807
Carotid plaque, n (%)	313 (58.1%)	307 (83.2%)	<0.001	2.591	4.934
Medication
Antiplatelet, n (%)	53 (9.8%)	62 (16.8%)	0.002	1.249	2.745
Anticoagulants, n (%)	6 (1.1%)	8 (2.2%)	0.205	0.677	5.721
Statin, n (%)	64 (11.9%)	48 (13.0%)	0.610	0.744	1.656
Dyslipidemia
Cholesterol ≥ 6.2 mmol/L, n (%)	33 (6.2%)	18 (5.0%)	0.430	0.437	1.424
Triglycerides ≥ 5.7 mmol/L, n (%)	20 (3.8%)	10 (2.8%)	0.412	0.335	1.568
LDL ≥ 4.14 mmol/L, n (%)	30 (5.6%)	23 (6.4%)	0.657	0.648	1.988
HDL ≤ 1 mmol L, n (%)	194 (36.5%)	141 (39.0%)	0.451	0.844	1.464
BPV subtype			<0.001
Dipper	162 (30.1%)	73 (19.8%)
Non-dipper	249 (46.2%)	172 (46.6%)
Reverse-dipper	112 (20.8%)	123 (33.3%)
Extreme-dipper	16 (3.0%)	1 (0.3%)

BPV, blood pressure variability; LDL, low-density lipoprotein; HDL, high-density lipoprotein; CI, confidence interval.