Table 3.

Association between hypernatremia exposure and delirium after cardiac surgery.

				95%CI for OR
Variable	Estimate	Wald	Adjusted OR	Lower	Upper	P Value
Hypernatremia	0.55	27.10	1.73	1.41	2.12	<0.001
Sex (Female)	−0.56	29.43	0.57	0.47	0.70	<0.001
Age (year)	0.03	51.75	1.03	1.03	1.04	<0.001
Hypertension	0.29	8.50	1.34	1.10	1.63	0.004
Diabetes	0.14	1.48	1.15	0.92	1.45	0.224
Myocardial infarction	0.23	1.62	1.26	0.88	1.80	0.204
Hyperlipidemia	−0.23	3.42	0.80	0.63	1.01	0.064
Cerebral vascular disease	0.13	0.80	1.14	0.86	1.52	0.37
Atrial fibrillation	−0.06	0.23	0.94	0.73	1.21	0.631
COPD	0.21	1.10	1.23	0.84	1.81	0.295
Heart failure	0.01	0.01	1.01	0.82	1.25	0.907
Kidney disease	0.37	4.93	1.44	1.04	1.99	0.026
Liver disease	0.70	13.03	2.02	1.38	2.96	<0.001
Operation time (h)	0.12	7.45	1.13	1.04	1.23	0.006
Heart valve surgery	−0.13	0.33	0.88	0.57	1.36	0.567
Isolated CABG	−0.17	0.66	0.84	0.56	1.27	0.416
CABG + Heart valve surgery	0.08	0.10	1.08	0.67	1.73	0.757
AD repair surgery (Open Heart)	0.94	13.96	2.57	1.57	4.21	<0.001
Intraoperative MAP fluctuation	0.03	0.12	1.03	0.86	1.24	0.729
Intraoperative blood loss (ml)	0.02	0.06	1.02	0.89	1.17	0.813
Intraoperative blood transfusion (ml)	0.10	3.24	1.10	0.99	1.23	0.072
Length of MV (h)	0.02	32.91	1.02	1.01	1.02	<0.001
Length of ICU stay (days)	0.05	2.18	1.05	0.98	1.13	0.14
Length of hospital stay (days)	−0.07	27.98	0.93	0.90	0.95	<0.001

CI, confidence interval; OR, odds ratio; COPD, chronic obstructive pulmonary disease; CABG, coronary artery bypass; AD, aortic dissection; MV, mechanical ventilation; MAP, mean artery pressure. Generalized estimating equation analysis was performed using a logistic link function, clustered by unique patient id. Comorbidities were included as Boolean and type of surgery was included as dummy variables.