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. 2022 Mar 9;13:857014. doi: 10.3389/fimmu.2022.857014

Table 5.

Drugs targeting more than or equal to two common DEGs. Black-bordered letters represent drugs targeting more than or equal to two hub DEGs.

Drug Target gene Effect
Cisplatin PIK3CA, STAT1 Antineoplastic
Doxorubicin CYP1B1, GATA3, NT5E, PIK3CA Antineoplastic
Vincristine ABCB4, GATA3, PIK3CA Antineoplastic
Benzquinamide ABCB4, CHRM3 Antihistaminic, Anticholinergic
Curcumin ABCB4, CAMK2A Antibacterial, anti-inflammatory, hypoglycemic,
    antioxidant, wound-healing, and antimicrobial activities
Celecoxib ALOX12, PIK3CA NSAID
Cyclophosphamide CYP1B1, GATA3 Antineoplastic, Immunosuppressant
Docetaxel CYP1B1, PIK3CA Antihistaminic
Fluorouracil CYP1B1, PIK3CA Antihistaminic
Letrozole CYP1B1, PIK3CA Aromatase inhibitor
Paclitaxel CYP1B1, PIK3CA Antihistaminic
Cetuximab NT5E, PIK3CA Antihistaminic