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. 2022 Mar 9;13:824831. doi: 10.3389/fpsyt.2022.824831

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Copyright © 2022 Mattingly, Ren, Christensen, Katzman, Polosan, Simonsen and Hammer-Helmich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adjusted LS mean (95% CI) score at baseline and after 12 and 24 weeks according to vortioxetine treatment line for (A) SDS total score, (B) PHQ-9, (C) PDQ-D-5, (D) ASEX, (E) DSST, and (F) EQ-5D-5L scores (full analysis set). ASEX, Arizona Sexual Experience Scale (score range 5–30); CI, confidence interval; DSST, Digit Symbol Substitution Test (score range 0–133); EQ-5D-5L, EuroQoL 5 dimensions 5 levels utility index (score range 0–1); LS, least-squares; PDQ-D-5, 5-item Perceived Deficits Questionnaire-Depression (score range 0–20); PHQ-9, 9-item Patient Health Questionnaire (score range, 0–27); SDS, Sheehan Disability Scale.