Table 3.

Adjusted LS mean change (SE) from baseline to week 24 for primary and secondary study endpoints (full analysis set).

Variable	Adjusted LS mean change (SE) from baseline to week 24
	Full cohort*	Patients with moderately severe to severe depression at baseline (PHQ-9 score ≥15)*
SDS total score	−8.7 (0.3)	−9.9 (0.4)
Work/school	−2.9 (0.2)	−3.3 (0.2)
Family life/home responsibilities	−2.9 (0.1)	−3.3 (0.2)
Social life/leisure activities	−3.0 (0.1)	−3.3 (0.2)
PHQ-9	−7.4 (0.3)	−9.4 (0.3)
CGI-S	−1.5 (0.1)	−1.7 (0.1)
PDQ-D-5	−4.6 (0.2)	−5.5 (0.3)
DSST	6.2 (0.5)	5.8 (0.7)
ASEX	−1.8 (0.2)	−2.1 (0.3)
EQ-5D-EL	0.13 (0.01)	0.15 (0.01)

ASEX, Arizona Sexual Experience Scale (score range 5–30); CGI-S, Clinical Global Impression–Severity (score range 1–7); DSST, Digit Symbol Substitution Test (score range 0–133); EQ-5D-5L, EuroQoL 5 dimensions 5 levels utility index (score range 0–1); LS, least-squares; MDD, major depressive disorder; MDE, major depressive episode; PDQ-D-5, 5-item Perceived Deficits Questionnaire-Depression (score range 0–20); PHQ-9, Patient Health Questionnaire (score range, 0–27); SE, standard error.

^*All changes, p <0.0001 vs. baseline.