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. Author manuscript; available in PMC: 2022 Sep 15.
Published in final edited form as: Nat Cell Biol. 2022 Mar 15;24(3):316–326. doi: 10.1038/s41556-022-00860-9

Extended Data Fig. 8: HER2 expression and cell cycle dynamics in human breast cancer tissues and HER2 driven mouse model of breast cancer.

Extended Data Fig. 8:

a. ccD-CMD plots for two HER2+ breast cancer tissue microarrays (TMA # 1 and #2) for increasing levels for HER2 protein. Single cells binned by normalized HER2 levels (n = 5,000 cells per bin were used). Right, ccD-CMD scatter plots of highest HER2 bin for both TMA1 and 2 with single marker normalized intensities mapped to color (n = 5,000 cells). b. ccD-CMD scatter plots of the single-cell data from MPI +1 cells from time course of HER2 induction and repression in GEMM with single marker normalized intensities mapped to color (n = 5,000 cells per plot, p27 was not used by the ccD-CMD algorithm). c. Mean +/− 25th percentile of circle fit distance of cell cycle markers in tumor cells (in situ and invasive) from Fig. 5h (n = 5,000 cells per plot).