Table 2.
Univariable and multivariable logistic regression of risk factor of bone metastasis in pancreatic carcinoma patients.
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | |
| Age | 0.984 (0.974-0.995) | 0.004 | 0.979 (0.967-0.990) | <0.001 |
| Race | ||||
| White | Reference | |||
| Black | 0.949 (0.609-1.415) | 0.807 | ||
| Other | 1.021 (0.630-1.568) | 0.929 | ||
| Sex | ||||
| Female | Reference | |||
| Male | 1.327 (1.023-1.727) | 0.034 | ||
| Histological subtype | ||||
| Adenocarcinoma | Reference | Reference | ||
| Infiltrating duct carcinoma | 0.264 (0.162-0.408) | <0.001 | 1.023 (0.607-1.647) | 0.928 |
| Neuroendocrine carcinoma | 1.322 (0.868-1.943) | 0.173 | 2.004 (1.219-3.198) | 0.005 |
| Other | 0.816 (0.552-1.171) | 0.287 | 1.089 (0.699-1.652) | 0.697 |
| Grade | ||||
| Well differentiated: I | Reference | |||
| Moderately differentiated: II | 1.675 (1.102-2.631) | <0.001 | ||
| Poorly differentiated: III | 2.338 (1.552-3.645) | 0.020 | ||
| Undifferentiated; anaplastic: IV | 6.363 (3.376-11.668) | <0.001 | ||
| Primary Site | ||||
| Head of pancreas | Reference | Reference | ||
| Body of pancreas | 2.378 (1.576-3.523) | <0.001 | 1.418 (0.919-2.151) | 0.106 |
| Tail of pancreas | 3.453 (2.484-4.795) | <0.001 | 2.793 (1.927-4.046) | <0.001 |
| Pancreatic duct | 3.656 (0.595-11.894) | 0.074 | 4.018 (0.616-14.724) | 0.072 |
| Other specified parts of pancreas | 4.010 (1.768-7.897) | <0.001 | 2.657 (1.099-5.619) | 0.018 |
| Overlapping lesion of pancreas | 3.213 (2.011-4.973) | <0.001 | 1.764 (1.066-2.835) | 0.022 |
| Pancreas, NOS | 3.389 (1.956-5.569) | <0.001 | 1.966 (1.110-3.348) | 0.017 |
| AJCC T stage | ||||
| T1 | Reference | |||
| T2 | 3.618 (1.958-7.471) | <0.001 | ||
| T3 | 1.435 (0.783-2.948) | 0.280 | ||
| T4 | 4.315 (2.309-8.976) | <0.001 | ||
| AJCC N stage | ||||
| N0 | Reference | Reference | ||
| N1 | 1.320 (1.019-1.718) | 0.037 | 1.703 (1.276-2.280) | <0.001 |
| Surgery | ||||
| No | Reference | Reference | ||
| Yes | 0.047 (0.028-0.073) | <0.001 | 0.072 (0.041-0.122) | <0.001 |
| Radiotherapy | ||||
| No | Reference | Reference | ||
| Yes | 1.474 (1.103-1.949) | 0.008 | 3.783 (2.679-5.310) | <0.001 |
| Chemotherapy | ||||
| No | Reference | |||
| Yes | 1.026 (0.792-1.335) | 0.846 | ||
| Tumor size | ||||
| 4-38 mm | Reference | |||
| 39-67 mm | 2.064 (1.559-2.737) | <0.001 | ||
| 68-150 mm | 3.251 (2.186-4.738) | <0.001 | ||
| Brain metastasis | ||||
| No | Reference | Reference | ||
| Yes | 76.044 (31.387-182.135) | <0.001 | 11.901 (4.139-33.936) | <0.001 |
| Liver metastasis | ||||
| No | Reference | Reference | ||
| Yes | 9.576 (7.326-12.607) | <0.001 | 3.044 (2.197-4.257) | <0.001 |
| Lung metastasis | ||||
| No | Reference | Reference | ||
| Yes | 13.424 (10.125-17.680) | <0.001 | 4.071 (2.962-5.566) | <0.001 |