Table 1.
Description of the study participants subdivided by different levels of FSI.
| Normal-FSI | Hyper-FSI | |||||
|---|---|---|---|---|---|---|
| Control (n = 80) | PCOS (n = 32) | P-value | Control (n = 59) | PCOS (n = 57) | P-value | |
| Age (year) | 31.00 (29.00-33.00) | 31.50 (30.00-32.75) | NS | 31.00 (29.00-34.00) | 32.00 (30.00-34.00) | NS |
| BMI (kg/m2) | 22.90 (21.53-24.30) | 23.55 (22.00-25.68) | NS | 25.60 (24.00-28.00) | 27.20 (24.65-29.02) | NS |
| Leptin (ng/mL) | 7.98 (4.95-11.45) | 12.27 (9.43-16.83) | P < 0.001 | 13.29 (9.01-16.86) | 15.66 (14.02-19.52) | P < 0.05 |
| FPG (mM) | 5.08 (4.90-5.30) | 5.04 (4.70-5.40) | NS | 5.45 (5.13-5.73) | 5.22 (4.99-5.66) | NS |
| FSI (mIU/L) | 9.25 (6.95-10.28) | 8.95 (7.43-10.18) | NS | 15.50 (14.00-19.60) | 19.00 (13.60-23.40) | NS |
| HOMA-IR | 2.10 (1.54-2.37) | 1.95 (1.56-2.42) | NS | 3.79 (3.20-4.92) | 4.36 (3.40-5.83) | NS |
| Free testosterone (nmol/L) | 0.021 (0.016-0.027) | 0.030 (0.018-0.038) | P < 0.05 | 0.026 (0.019-0.034) | 0.031 (0.023-0.042) | P < 0.05 |
| DHEAS (nmol/L) | 2961 (1965-3695) | 4059 (2830-5592) | P < 0.05 | 3307 (2217-4502) | 4519 (3039-6375) | P < 0.05 |
| Total testosterone (ng/mL) | 0.48 (0.35-0.57) | 0.63 (0.54-0.73) | P < 0.001 | 0.51 (0.37-0.61) | 0.73 (0.52-0.87) | P < 0.001 |
| FSH (mIU/L) | 7.26 (6.17-8.73) | 6.45 (5.73-7.51) | P < 0.05 | 6.93 (5.58-7.64) | 6.26 (5.12-7.78) | NS |
| LH (mIU/L) | 3.84 (2.96-5.09) | 11.31 (5.80-11.01) | P < 0.001 | 3.65 (2.88-5.39) | 9.43 (5.27-13.44) | P < 0.001 |
| LDL-C (mM) | 2.65 ± 0.70 | 3.04 ± 0.70 | P < 0.05 | 2.71 ± 0.69 | 3.08 ± 0.76 | P < 0.05 |
| HDL-C (mM) | 1.28 (1.12-1.53) | 1.30 (1.08-1.50) | NS | 1.13 (0.95-1.33) | 1.06 (0.90-1.17) | NS |
| Prolactin (ng/mL) | 10.35 (8.45-13.48) | 8.80 (7.59-11.01) | P < 0.05 | 10.40 (7.83-13.47) | 9.38 (6.95-12.54) | NS |
| Progestin (mIU/mL) | 0.55 (0.33-0.69) | 0.53 (0.36-0.88) | NS | 0.53 (0.36-0.81) | 0.56 (0.35-1.11) | NS |
| AMH (ng/mL) | 3.08 (1.28-4.54) | 9.49 (7.16-12.31) | P < 0.001 | 2.95 (1.50-5.41) | 7.10 (4.79-11.12) | P < 0.001 |
| Estrogen (pg/mL) | 46.00 (35.00-65.25) | 52.00 (38.00-69.00) | NS | 47.00 (38.50-62.50) | 53.00 (40.00-67.00) | NS |
| Total cholesterol (mM) | 4.49 ± 0.78 | 4.79 ± 0.87 | NS | 4.39 ± 0.84 | 4.94 ± 0.83 | P < 0.05 |
| Triglycerides (mM) | 1.28 (1.12-1.53) | 1.15 (0.92-1.53) | P < 0.05 | 1.39 (0.91-1.92) | 1.90 (1.19-2.48) | P < 0.05 |
| TSH (µIU/mL) | 1.81 (1.38-2.49) | 1.72 (1.20-2.08) | NS | 1.89 (1.51-2.72) | 1.80 (1.18-2.36) | NS |
AMH, anti-Müllerian hormone; BMI, body mass index; DHEAS, dehydroepiandrosterone sulfate; FSH, follicle-stimulating hormone; FSI, fasting serum insulin; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; LDL-C, low-density lipoprotein cholesterol; LH, luteinizing hormone; TSH, thyroid-stimulating hormone; NS, not significant. Mean ± standard deviation or median (interquartile range) are shown. The Mann-Whitney U test was used for non-normally distributed data, and Student’s t test was used for normally distributed data.