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. 2022 Mar 9;13:847387. doi: 10.3389/fphar.2022.847387

FIGURE 3.

FIGURE 3

Diagram of inhibition by DKK1 inhibitors. LINC01133 methylates the DKK1 promoter, but GATA6 and MSX1 directly bind to the DKK1 promoter. After the transcription of DKK1 DNA, DKK1-AS1 and DKK1-AS2 bind to nucleotides 4–21 and 243–260 of DKK1 mRNA, respectively. MiRNAs bind to the 3′-UTR of DKK1 mRNA, but siRNAs bind to the translational region. DKK1 antibodies specifically interact with DKK1 protein, but different antibodies bind to distinct domains of DKK1, and a cyclized oligopeptide competitively binds with LRP5/6 and therefore blocks the DKK1-LRP5/6 interaction because it has the same NXI motif as the DKK1 protein. NCI8642 is a small molecule that can function as a DKK1 inhibitor by suppressing the DKK1-LRP5/6 interaction.