TABLE 1.

Development of antibodies against DKK1.

Antibodies	Model(s)	Disease(s)	References
BHQ880	5T2MM murine model of myeloma	MM	Heath et al. (2009)
	SCID-hu mouse model of human myeloma	MM	Fulciniti et al. (2009)
	Orthotopic patient-derived xenograft model of osteosarcoma	Osteosarcoma	Goldstein et al. (2016)
DKN-01	Patients with relapsed/refractory esophagogastric cancer	Esophagogastric cancer	Wall et al. (2020)
	Patients with biliary tract cancer	Biliary tract cancer	Goyal et al. (2020)
	C57BL/6 mice	Ovarian cancer	Betella et al. (2019)
	ID8 syngeneic mice	Epithelial ovarian cancer	Betella et al. (2020)
	Patients with MM or advanced solid tumors	MM or advanced solid tumors	Ryan et al. (2016)
	Gynecologic malignancy patients	Gynecologic malignancies	Arend et al. (2019a)
	NSCLC patients	NSCLC	Edenfield et al. (2014)
RH2-18	Ovariectomized C57BL/6NTac mice and rhesus macaques	Postmenopausal osteoporosis	Glantschnig et al. (2011)
Hetero-DS	Femur fracture model in rats	Fracture	Florio et al. (2016)
	Cynomolgus monkey	Postmenopausal osteoporosis	Florio et al. (2016)