. Author manuscript; available in PMC: 2022 Mar 28.

Published in final edited form as: Ann Eye Sci. 2022 Mar 15;7:7. doi: 10.21037/aes-21-30

Table 3:

Murine model, features, and references of transgenic mice used for UM

Mouse Model	Model Features	References
TySV40	Bilateral intraocular tumor developed and metastasis was found in the liver.	(118)
Tyr-SV40E	Mice developed ocular and cutaneous melanomas. Diffuse metastasis to various internal organs was seen.	(109)
RET.AAD	Pigmented tumors were first observed in the choroid and ciliary body. Metastasis were found in various internal organs.	(115)
Tg(Grm1)EPv	Pigmented choroidal tumors developed in the mice. Hepatic metastases were noted.	(117)
Tyr-Tag	Mice develop intraocular tumors similar to human UM. Metastasis was observed in subcutaneous tissue, lung and brain.	(119)
TRP-1/Tag	Tumors of pigmented and epithelial cell origin developed in the mice and metastasis was detected in the spleen and inguinal lymph nodes within 3 months.	(120)

TRP-1, tyrosinase-related protein 1 promoter.