Table 4:

Models for induction and comparison of advantages and disadvantages in UM research.

Induction Method	Advantages	Disadvantages
Chemical/radiation induced mutations	High mutational rate; minimal cost for induction of mutation	Random integrative mutations; difficult to associate specific mutations with pathologies
Retroviral infection	Insertion of specific gene; low controlled events	De novo DNA methylation; vector capacity in large genes; random integration in the genome
Microinjection of DNA constructs	Direct insertion of specific gene	Random integration in the genome