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. 2022 Mar 9;13:811551. doi: 10.3389/fimmu.2022.811551

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Copyright © 2022 Wu, Roberto, Knupp, Greninger, Truong, Hollingshead, Kenerson, Tuefferd, Chen, Koelle, Horton, Jerome, Polyak, Yeung and Crispe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of trichrome stain, picrosirius red stain, and H&E stain analysis of human liver slices. Arrow indicates the nodule formation in the cirrhosis livers. The Scheuer/Batts-Ludwig method was used for fibrosis scoring, with 0, No fibrosis; 1, portal fibrosis; 2, peri-portal fibrosis; 3, bridging fibrosis; and 4, cirrhosis. The DAA-4 liver tissue was collected 12 months after the completion of 24-week DAA therapy. DAA-9 liver tissue was collected 20 months after the completion of 12-week DAA therapy.