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. 2022 Mar 9;12:854879. doi: 10.3389/fcimb.2022.854879

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Copyright © 2022 Sun, Xin, An, Hu and Feng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbial regulation of Bile Acids in NAFLD. ①: Microbial modification of primary BAs to secondary BAs. ②: Microbial regulation of BAs synthesis. ③: Microbial regulation of BAs transport, and reabsorption. (BESP, bile salt export pump; MRP2, multidrug resistance protien 2; BAs, bile acids; BSH, bile salt hydrolase; β-MCA, β-murocholic acid; CA, Cholic acid; CDCA, Chenodeoxycholic acid; CYP7A1, cytochrome P450 family 27 subfamily A member 1; CYP7B1, cytochrome P450 family 7 subfamily B member 1; DCA, deoxycholic acid; FXR, farnesoid X receptor; FFA, free fatty acid; IBABP, ileal bile acid binding protein; LCA, lithocholic acid; NAFLD, non-alcoholic fatty liver disease; SHP, small heterodimer partner; SREBP-1, sterol regulatory element binding protein-1; TβMCA, tauro-β-muricholic acid; TC, total cholesterol; TMAO, trimethylamine oxide; UDCA, ursodeoxycholic).