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Effect of fluoroquinolone structure on bacteriostatic activity against resistant gyrase. Normalized MIC99s of gyrA parC mutants (Fig. 2B) are expressed as gatifloxacin/AM1121 MIC99 ratios. Filled bars represent alleles located in α-helix 4 according to reference 14; open bars represent alleles outside α-helix 4. The values shown are the averages of two independent determinations. Error bars indicate the upper ranges of the determinations.
