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Bactericidal action of fluoroquinolones against resistant gyrA and gyrA parC mutants in the presence of chloramphenicol. The survival rates of mutants were determined following a 2-h incubation in chloramphenicol plus gatifloxacin (filled bars), AM1121 (shaded bars), or ciprofloxacin (open bars) at 10 times the respective MIC99s (A) gyrA mutant strains; (B) gyrA parC double mutant strains. The data shown are the averages of two determinations.
