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. 2022 Mar 9;10:838415. doi: 10.3389/fbioe.2022.838415

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Copyright © 2022 Moss, Ortiz-Hernandez, Levin, Richburg, Gerton, Cook, Houlton, Rizvi, Goodwin, Golway, Ripley and Hoying.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Implanted grafts progressively mineralize over the 8-week period as assessed by microCT imaging. (A) Time course of graft ossification for the 5 grafts implanted for 8 weeks. (B) Projections of rendered microCT scans for graft 687 from week 5 through week 8 showing the spatial progression of ossification within the graft. (C) 3D renderings of graft #687 implant thresholded to show bone-equivalent density and internal structure. Scale bars in all panels equal 1 cm.