TABLE 2.
Results of before–after analysis by pathogenic variant type.
| Nonsynonymous CG (N = 16) | Nonsynonymous IG (N = 38) | LOF CG (N = 157) | LOF IG (N = 155) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Mean ± SD | Six months Mean ± SD | p * | Baseline Mean ± SD | Six months Mean ± SD | p * | Baseline Mean ± SD | Six months Mean ± SD | p * | Baseline Mean ± SD | Six months Mean ± SD | p * | |
| Weight (kg) | 67.0 ± 15.4 | 66.3 ± 13.8 | 0.44 | 64.5 ± 10.8 | 63.2 ± 11.4 | 0.03 | 65.2 ± 13.6 | 64.5 ± 13.5 | <0.01 | 61.5 ± 10.5 | 60.1 ± 10.5 | <0.01 |
| BMI (kg/m2) | 25.1 ± 6.1 | 24.9 ± 5.5 | 0.43 | 25.1 ± 4.5 | 24.5 ± 4.5 | 0.03 | 24.7 ± 4.8 | 24.4 ± 4.7 | <0.01 | 23.6 ± 4.3 | 23.1 ± 4.2 | <0.01 |
| Waist circumference (cm) | 78.3 ± 12.9 | 78.0 ± 12.3 | 0.74 | 79.3 ± 10.9 | 77.2 ± 12.0 | 0.04 | 79.0 ± 13.3 | 78.2 ± 12.6 | 0.03 | 76.4 ± 10.4 | 74.6 ± 10.0 | <0.01 |
| Hip circumference (cm) | 104.7 ± 11.1 | 104.2 ± 9.8 | 0.53 | 100.5 ± 7.6 | 99.3 ± 8.7 | 0.06 | 100.4 ± 10.0 | 99.9 ± 10.2 | 0.17 | 97.9 ± 9.3 | 96.2 ± 8.8 | <0.01 |
| Systolic pressure (mmHg) | 119.8 ± 16.8 | 123.1 ± 14.7 | 0.27 | 124.3 ± 15.5 | 124.6 ± 12.8 | 0.91 | 124.9 ± 15.4 | 120.8 ± 13.8 | <0.01 | 126.6 ± 18.6 | 122.5 ± 15.3 | <0.01 |
| Diastolic pressure (mmHg) | 80.3 ± 10.5 | 80.4 ± 9.1 | 0.91 | 83.2 ± 11.6 | 81.9 ± 10.5 | 0.46 | 81.4 ± 10.6 | 78.9 ± 9.1 | <0.01 | 82.1 ± 11.1 | 79.4 ± 11.0 | <0.01 |
| Glycemia (mg/dl) | 100.7 ± 22.3 | 89.9 ± 21.8 | 0.18 | 98.4 ± 21.9 | 90.2 ± 14.6 | 0.03 | 102.3 ± 24.4 | 93.4 ± 20.0 | <0.01 | 101.7 ± 22.3 | 94.5 ± 19.2 | <0.01 |
| Total cholesterol (mg/dl) | 202.6 ± 36.8 | 193.6 ± 26.0 | 0.23 | 198.5 ± 33.8 | 190.4 ± 29.6 | 0.03 | 198.6 ± 38.5 | 194.0 ± 39.1 | 0.04 | 201.9 ± 40.4 | 190.2 ± 34.9 | <0.01 |
| HDL cholesterol (mg/dl) | 70.3 ± 15.7 | 70.0 ± 18.8 | 0.91 | 68.9 ± 19.1 | 66.1 ± 16.9 | 0.16 | 69.2 ± 18.9 | 69.1 ± 18.2 | 0.94 | 68.6 ± 15.7 | 66.6 ± 15.2 | 0.05 |
| LDL cholesterol (mg/dl) | 119.4 ± 28.9 | 108.6 ± 19.7 | 0.10 | 113.6 ± 34.7 | 111.6 ± 29.4 | 0.58 | 117.5 ± 35.9 | 111.5 ± 35.1 | <0.01 | 120.4 ± 36.9 | 113.5 ± 34.7 | <0.01 |
| Triglycerides (mg/dl) | 83.6 ± 35.0 | 89.1 ± 43.4 | 0.62 | 116.6 ± 127.3 | 98.6 ± 44.9 | 0.28 | 103.6 ± 58.8 | 109.5 ± 62.7 | 0.10 | 101.3 ± 50.5 | 95.3 ± 46.2 | 0.14 |
| IGF-I (ng/ml) | 184.6 ± 71.3 | 184.8 ± 73.9 | 0.99 | 175.3 ± 58.7 | 164.8 ± 66.3 | 0.10 | 170.3 ± 70.0 | 169.4 ± 62.6 | 0.80 | 179.5 ± 70.8 | 170.3 ± 75.1 | <0.01 |
| Insulin (µIU/ml) | 19.4 ± 9.6 | 16.6 ± 13.8 | 0.53 | 16.9 ± 10.6 | 13.6 ± 10.3 | 0.14 | 19.5 ± 17.2 | 14.6 ± 12.5 | <0.01 | 22.1 ± 20.0 | 13.3 ± 12.0 | <0.01 |
| CRP (mg/L) | 2.4 ± 1.7 | 1.6 ± 1.2 | 0.01 | 1.6 ± 1.7 | 2.1 ± 2.8 | 0.30 | 2.0 ± 2.7 | 1.7 ± 2.3 | 0.18 | 1.7 ± 2.1 | 1.4 ± 1.9 | 0.04 |
*
p of t-test for difference between baseline and 6 months by randomization group.