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. 2022 Mar 9;10:823450. doi: 10.3389/fcell.2022.823450

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Copyright © 2022 Yaker, Tebani, Lesueur, Dias, Jung, Bekri, Guerrera, Kamel, Ausseil and Boullier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Volcano plot representing the effects of lipopolysaccharide-EK (LPS-EK) on the protein content of macrophage-derived extracellular vesicles (EVs). EVs were isolated from the culture media of RAW cells incubated with (EV-LPS) or without (EV-CT6) lipopolysaccharide-EK (LPS-EK). High-performance liquid chromatography (HPLC) coupled to mass spectrometry analysis was performed. An unpaired Student’s t test was conducted and a p-value < 0.01 and a false discovery rate (FDR) < 5% were used. Five independent experiments were performed.