TABLE 3.
Pathway mapping of force-related lncRNAs.
| LncRNA | Clarified information | ||
| Background | Reported target and function | Pathway | |
| NEAT1 | HBMSC (Zhang X et al., 2019) | Promoting osteogenic differentiation via miR-29b-3p/BMP1 axis | BMP |
| cancer cell lines (Todorovski et al., 2020) | Mediate the mechanomemory to substrate stiffness via H3K27me3 activity | EZH2 | |
| H19 | HBMSC (Wu et al., 2018) | Promoting osteogenesis under tension via sponging miR-138 to release PTK2 | FAK-ERK1/2-Runx2 |
| UMR-106 (Li et al., 2018) | Positively related to osteogenesis under mechanical unloading via DNMT1/H19/Erk | ERK-MAPK | |
| UMR-106 (Li et al., 2017) | Positively related to osteogenesis under mechanical unloading via Dkk4 | Wnt/β-catenin | |
| MC3T3-E1 (Wu et al., 2019a) | Promoting matrix mineralization via miR-185-5p/IGF1 | IGF1 | |
| HBMSCs (Bi et al., 2020) | Promoting osteogenic differentiation via miR-140-5p/SATB2 | SATB2 | |
| REMSCs (Gong et al., 2018) | Promoting osteogenic differentiation via miR-22, miR-141/β-catenin | Wnt/β-catenin | |
| HBMSC (Xiaoling et al., 2020) | Elevates cell proliferation and differentiation of BMSCs via miR-19b-3p | ||
| KCNQ1OT1 | HBMSCs (Wang J. L et al.,2020) | Promoting osteoblast generation via miR-320a/Smad5 | Cbfa1/Runx2 |
| HBMSCs (WangC.-G. et al., 2019) | Promoting osteogenic differentiation via miR-214/BMP2 | BMP2 | |
| MTSPCs (Yu et al., 2018b) | Promoting osteogenic differentiation via miR-138 | RUNX2/PPARγ | |
| Hc-a cells (Gu H. et al., 2019) | A potential biomarker of delayed fracture healing of patients promoting cellular proliferation and inhibiting apoptosis | Wnt/β-catenin | |
| TUG1 | MTSPCs (Yu et al., 2020) | Promoting osteogenic differentiation via promoting the ubiquitination of bFGF | bFGF |
| HPDLSCs (He et al., 2018) | Promoting osteogenic differentiation via lin-28 homolog A (Lin28A) | ||
| HPDLSCs (Wu D. et al., 2020) | Promoting osteogenic differentiation via miR-222-3p/Smad2/7 | Smad | |
| Osteoblast (Liu S. C et al., 2019b) | Promoting osteoblast proliferation and differentiation | Wnt/β-catenin | |
| Valve interstitial cells (Yu C. et al., 2018) | Promoting osteogenic differentiation via miR-204/Runx2 | Runx2 | |
| SNHG1 | HBMSCs (Xiang et al., 2020) | Attenuating the osteogenesis via the miR-101/DKK1 axis | Wnt/β-catenin |
| MBMSCs (Jiang et al., 2019) | Inhibiting osteogenic differentiation via Nedd4 | p38 MAPK | |
| Prostate cancer (Chen et al., 2020) | Binding to EZH2 and exerting proto-oncogene effect | Wnt/β-catenin, PI3K/AKT/mTOR | |
| Osteosarcoma cells (Deng et al., 2019) | A negative regulator via miR-101-3p/ROCK1 pathway | ROCK1 | |
| MALAT1 | RBMSCs (Zheng et al., 2019b) | Inhibiting osteogenic differentiation | MAPK |
| Esophageal cancer (Yao et al., 2019) | Direct binding to enhance YAP activity | YAP/TAZ | |
| Acute pancreatitis (Gu L. et al., 2019) | Forming a loop as MALAT1/miR-194/YAP1 | YAP/TAZ | |
| Non-small-cell lung cancer (Jin et al., 2019) | Forming a loop as MALAT1/miR-1914-3p/YAP | YAP/TAZ | |
| Valve interstitial cells (Xiao et al., 2017) | Promoting osteogenic differentiation via miR-204/Smad4 | Smad | |
| Osteosarcoma (Cai et al.,2016) | Facilitating the metastasis | RhoA/ROCK | |
| NORAD | Lung/breast cancer (Tan et al.,2019) | Transcriptionally repressed by the YAP/TAZ-TEAD complex | YAP/TAZ |
| Hepatocellular carcinoma (Kawasaki et al.,2018; Yang et al.,2019) | Regulating epithelial-to-mesenchymal transition-like phenotype | TGF-β | |
| Promoting cancerous progression via miR-202-5p | |||
| Breast cancer (Zhou et al.,2019) | Promoting cancerous progression | TGF-β | |
| OIP5-AS1 | Valve interstitial cells (Zhu et al., 2019) | Promoting osteogenic differentiation via miR-137/TWIST11 | TWIST11 |
| SNHG16 | Colorectal cancer (Christensen et al.,2016) | Regulated by Wnt activity | Wnt/β-catenin |
| Cervical cancer (Wu W. et al., 2020) | Function via the SNHG16/miR-128 axis | Wnt/β-catenin | |
| LINC-00662 | Hepatocellular carcinoma (Tian et al., 2020) | Facilitating WNT3A secretion | Wnt/β-catenin |
| MCM3AP-AS1 | Chondrocytes (Gao et al.,2019) | Increasing apoptotic rate of chondrocytes via miR-142-3p/HMGB1 | |