TABLE 4.
Creditable force-sensitive lncRNAs and related pathways.
| Evidence | Samples | Force | lncRNA | Exp | Pathway | |
| Liu H. et al. (2019) | HiSeq 2000 (Illumina) | OCCM-30 | CF | 70 lncRNAs: 57 upregulated, 13 downregulated | KEGG pathway analyses of DEGs: HIF-1, FoxO, mTOR, Notch, and Rap1 signaling pathways | |
| qPCR | Prkcz2, Hklos, Trp53cor1, Gdap10, Ak312-ps | Up | ||||
| Hu et al. (2017) | Affymetrix GeneChip | MC3T3-E1 | RWVB | 857 lncRNAs: 168 upregulated, 689 downregulated | ||
| Bioinformatics qPCR | NONMMUT044983 | down | Ptbp2: CaV1.2 calcium channel transcript | |||
| NONMMUT018832 | Tnpo1: nuclear translocation of oxytocin receptors | |||||
| NONMMUT023474 | Ext1: BMP signaling | |||||
| Huang et al. (2019) | HiSeq 2000 system (Illumina) | hPDLSCs | CF | 90 lncRNAs: 72 upregulated, 18 downregulated | KEGG of DEGs: ECM–receptor interaction, focal adhesion, HIF-1, PI3K/Akt, protein digestion and absorption, and glycolysis/gluconeogenesis | |
| qPCR | ||||||
| FER1L4, HIF1A-AS2, MIAT, NEAT1, ADAMTS9-AS2, LUCAT1 | up | |||||
| MIR31HG, DHFRP1 | down | |||||
| Huang et al. (2021) | functional | PDLSCs; Mice | CF OTM | Fer1l4 | up | AKT/FOXO3 |
| Zhang X. et al. (2019) | functional | HPDLCs; Rats | CF OTM | DANCR | up | miR-34a-5p/DANCR/Jagged1 (Notch signaling pathway) |
| Li et al. (2017) | Illumina HiSeq 2500 | Rats | HLU | 464 lncRNA: 83 upregulated, 381 downregulated | ||
| bioinformatics | H19 | down | Dkk4/Wnt/β-catenin signaling; TGF-beta, and tight junction pathways | |||
| functional | ||||||
| Wu et al. (2018) | functional | hBMSCs | CTS | H19 | up | H19–miR-138–PTK2(FAK) |
| Yan et al. (2021) | functional | U-MSCs to chondrocyte; rats | RCCS | H19 | up | RCCS significantly promoted exosome production and exosomal lncRNA H19 at 36 rpm/min within 196 h |
| Li et al. (2018) | functional | UMR-106; rats | HLU | H19 | down | DNMT1–hypermethylation of H19 promoter–ERK signaling; TGF-β, WNT, and JAK-STAT pathways |
| Zhang et al. (2018) | Affymetrix GeneChip | C2C12; Mice | HLU | lncMUMA | down | miR-762/MyoD |
| RPM | ||||||
| Wang M et al. (2020) | Microarray functional | hBMSCs | Topography | lncRNA PWRN1-209 | up | integrin-FAK-ALP signaling |
| Wang Y et al. (2020) | functional | MC3T3-E1; Mice | HLU | ODSM | up | partially dependent on miR-139-3p/ELK1 |
| Liu et al. (2016) | Microarray (Arraystar) | human chondrocytes | CTS | 107 lncRNAs: 51 upregulated, 56 downregulated | ||
| functional | lncRNA-MSR | up | miRNA-152/TMSB4 | |||
| microarray | lncRNA-CIR | up | vimentin | |||
| Izadpanahi et al. (2018) | bioinformatics | hASCs | Topography | MEG3 | up | controlled by miR-125b |
| qPCR | ||||||
| qPCR | H19 | up | BMP signaling | |||
| Wang K et al. (2020) | functional | MC3T3-E1 | Clinostat | OGRU | down | miR-320-3p/Hoxa10 axis-Runx2 |
| Mice | ||||||
CF, compressive force; RWVB, rotating wall vessel bioreactor; OTM, orthodontic tooth movement; HLU, hind limb unloading; CTS, cyclic tensile strain; RCCS, rotary cell culture system; RPM, random positioning machine; hPDLSCs, human/mouse periodontal ligament stem cells; hPDLC, human periodontal ligament cells; hBMSC, human bone marrow-derived stem cells; hADSCs, human adipose tissue-derived stem cells hADSCs, human adipose tissue-derived stem cells.