Table 2.
Previous cases of PI/PCI post etoposide-based chemotherapy
| Case [Ref.] | Sex/Age (yr) | Underlying disease | Chemotherapy | Causative agent, dose | Location | Diagnostic tools | Associated symptoms | Complications | Treatments | Outcome | Time to recovery |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 [29] | M/58 | Lymphoma | NA | Etoposide, NA | Total colon | X-ray + CT | None | No | Parenteral nutrition antibiotics | Resolved | 30 days |
| 2 [32] | M/51 | Lymphoma | MNCOP-V | Etoposide, 100 mg | Total colon | X-ray | Septicemia and abdominal discomfort | No | Oxygen therapy parental nutrition antibiotics | Resolved | NA |
| 3 [32] | F/58 | Lymphoma | MNCOP-V | Etoposide, 95 mg | Total colon + terminal ileum | X-ray | Slight abdominal distension | No | Oxygen therapy parental nutrition | Resolved | 1 week |
| 4 [32] | M/74 | AML-M2 | NA | Etoposide, NA | Total colon | X-ray | Abdominal distension | No | Oxygen therapy parental nutrition | Resolved | 2 weeks |
| 5 [34] | F/53 | Breast cancer | Various | Etoposide, 50 mg qd | Total colon + rectum | X-ray + CT + colonoscopy | Severe abdominal distension with decreased flatus | No | Oxygen therapy antibiotics | Resolved | 3 weeks |
| 6 [35] | M/69 | Small cell lung cancer | Carboplatin (d1) + etoposide (d1–3) | Etoposide, 100 mg | Sigmoid colon + retroperitoneum + posterior mediastinum | CT | Abdominal distension | No | Oxygen therapy antibiotics | Resolved | 2 weeks |
M male, F female, AML acute myeloid leukemia, MNCOP-V methotrexate with leucovorin rescue, mitoxantrone, cyclophosphamide, vincristine, prednisolone and etoposide, NA not available