Table 1.
Publicly available datasets used for discovery of the 8-gene set and training of the 8-gene XGBoost model. Healthy controls, convalescent patients, and patients with other febrile illnesses were removed. Longitudinal samples were excluded for gene set discovery and model training but included for temporal gene expression analysis (included in “Total samples used”). WB, whole blood; PBMC, peripheral blood mononuclear cells
| Dataset | Platform | Year | Reference | Country | Age | Tissue | Samples used in discovery | Total samples used |
|---|---|---|---|---|---|---|---|---|
| GSE40628 | GPL16021 (Lymphochip) | 2007 | Simmons CP [25] | Vietnam | Adults | WB | 14 | 14 |
| GSE18090 | GPL570 (Affymetrix) | 2009 | Nascimento EJ [26] | Brazil | Adults | PBMC | 18 | 18 |
| GSE13052 | GPL2700 (Illumina) | 2009 | Long HT [27] | Vietnam | Children | WB | 18 | 18 |
| GSE25001 | GPL6104 (Illumina) | 2010 | Hoang LT [28] | Vietnam | Children/adults | WB | 96 | 168 |
| GSE17924 | GPL4133 (Agilent) | 2010 | Devignot S [29] | Cambodia | Children | WB | 48 | 48 |
| GSE38246 | GPL15615 (Illumina) | 2012 | Popper SJ [30] | Nicaragua | Children | PBMC | 41 | 102 |
| GSE43777 | GPL201 (Affymetrix) | 2013 | Sun P [31] | Venezuela | Children/adults | PBMC | 26 | 112 |
| GSE43777 | GPL570 (Affymetrix) | 2013 | Sun P [31] | Venezuela | Children/adults | PBMC | 20 | 74 |
| GSE51808 | GPL13158 (Affymetrix) | 2014 | Kwissa M [32] | Thailand | Adults | WB | 28 | 28 |
| GSE94892 | GPL16791 (Illumina) | 2017 | Banerjee A [14] | India | Children/adults | PBMC | 31 | 31 |
| GSE100299 | GPL17586 (Affymetrix) | 2017 | Simon-Lorière E [15] | Cambodia | Children | PBMC | 25 | 25 |
| Total | 365 | 638 | ||||||