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. 2022 Mar 9;9:852918. doi: 10.3389/fmed.2022.852918

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Copyright © 2022 Schaefer, Trujillo-Vargas, Midani, Pflugfelder, Britton and de Paiva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Offspring of SS-humanized mice also have fewer CD4⁺ FOXP3⁺ cells in the CLN as well as spleen, demonstrating vertical transmission. Cumulative flow cytometry data showing percentage of CD4⁺ FOXP3⁺ cells from CLN, spleen, MLN, and lamina propria of 8-week-old offspring of mice gavaged with patient stools. CLN, cervical draining lymph nodes; MLN, mesenchymal lymph nodes; LP, lamina propria. Statistical significance was assessed using non-parametric Mann-Whitney U-tests. *P ≤ 0.05, **P ≤ 0.01, ns, not significant.