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. 2022 Mar 9;9:820224. doi: 10.3389/fnut.2022.820224

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Copyright © 2022 Nieto-Ruiz, García-Santos, Verdejo-Román, Diéguez, Sepúlveda-Valbuena, Herrmann, Cerdó, De-Castellar, Jiménez, Bermúdez, Pérez-García, Miranda, López-Sabater, Catena and Campoy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Participant flow-chart from baseline visit to 6 years old. BF, Breastfed infants; D, Drop-outs; E, Exclusions; EF, Experimental infant formula; MRI, Magnetic Resonance Imaging; n, Sample size; R, Recovered; SF, Standard infant formula. Fatty acid (FA) status was analyzed from available cheek cell samples of children who attended to 6 years follow-up visit. Incomplete dietary intake data were excluded from the current analysis. At 6 years old: *2 children did not attend to cognitive assessment. Some MRI data from participants (n = 30) were eliminated because the quality of the brain images was not adequate to be analyzed due to excessive movement of children inside the scanner: Unable to analyze the data from 7 children; ^‡Unable to analyze the data from 14 children; ^§Unable to analyze the data from 11 children. ^aBF infants were randomized between 0–6 months of age.