Table 6.

Potential long-term effects of fatty acids status during the first 18 months of life on children's brain structure at 6 years old^a.

	Fatty acids
Brain regions	6 months				12 months		18 months
Volume (cm3)	ARA	EPA	DHA	ARA/DHA	DHA	ARA/DHA	DHA	ARA/DHA
Right parietal	β = 0.176 P = 0.021	N/S	β = 0.330 P<0.001	β = −0.374 P < 0.001	β = 0.341 P < 0.001	β = −0.291 P < 0.001	β = 0.295 P < 0.010	β = −0.313 P < 0.001
Left orbital	N/S	N/S	N/S	N/S	N/S	N/S	N/S	N/S
Right postcentral gyrus	N/S	N/S	β = 0.261 P = 0.021	β = −0.344 P = 0.002	N/S	N/S	N/S	N/S
Right precuneus	β = 0.203 P = 0.039	N/S	β = 0.340 P = 0.001	β = −0.385 P < 0.001	β = 0.350 P = 0.001	β = −0.249 P = 0.013	N/S	β = −0.350 P = 0.001
Cortical thickness (mm)
Left circular insular sulcus	N/S	β = 0.315 P = 0.012	N/S	N/S	N/S	N/S	N/S	N/S
Left occipito–temporal sulcus	N/S	N/S	N/S	N/S	N/S	N/S	N/S	N/S
Right postcentral sulcus	N/S	N/S	N/S	N/S	N/S	N/S	N/S	N/S

^aP-values for linear regression analysis. P-values < 0.05 are highlighted in bold.

ARA, Arachidonic acid; EPA, Eicosapentaenoic acid; DHA, Docosahexaenoic acid; ARA/DHA, Arachidonic acid/Docosahexaenoic acid ratio; β, Beta coefficient; N/S, Not significance.