TABLE 1.

Discrimination between apoptosis and pyroptosis.

	Apoptosis	Pyroptosis
Common point	Programmed cell death
Characteristic	Cell shrinkage	Cell enlarging
	Membrane blebbing	Membrane broken
	Nuclear DNA fragmentation	Organelles deforming
	Nuclear condensation	DNA randomly degraded
	—	Chromatin condensation
Dependence on caspases Transformation to apoptosis and pyroptosis	Caspase 3, 6, 7, 8,9, 10	Caspase 1, 3, 4, 5, 11
	caspases that activate GSDM members: ①GSDMC by caspase-8 Watabe et al. (2001); ②GSDMD by caspase-1, and to a lesser extent, by caspase-8 Orning et al. (2018), Sarhan et al. (2018); ③GSDME by caspase-3 Rogers et al. (2017), Wang et al. (2017)