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. 2022 Mar 9;9:774224. doi: 10.3389/fmed.2022.774224

Table 2.

The deaths due to infective endocarditis in 1990/2019 and temporal trends.

Characteristics 1990 2019 1990–2019
Death No × 103 (95% CI) ASDR/105 No. (95% CI) Death No × 103 (95% CI) ASDR/105 No. (95% CI) EAPC No. (95% CI)
Overall 28.75 (24.37~35.7) 0.73 (0.63~0.93) 66.32 (46.21~75.86) 0.87 (0.59~1) 0.71 (0.44~0.98)
Sex
Male 14.72 (12.06~18.7) 0.77 (0.65~1.02) 32.63 (22.3~37.64) 0.94 (0.62~1.09) 0.79 (0.57~1.01)
Female 14.03 (10.94~18.81) 0.66 (0.53~0.91) 33.69 (21.43~39.18) 0.78 (0.5~0.91) 0.66 (0.35~0.96)
Socio-demographic factor
High SDI 7.19 (5.9~11.49) 0.71 (0.58~1.12) 24.68 (11.73~30.81) 1.16 (0.58~1.43) 2.01 (1.51~2.51)
High-middle SDI 5.94 (4.99~7.71) 0.6 (0.5~0.78) 13.26 (9.19~15.08) 0.71 (0.49~0.8) 0.62 (0.38~0.86)
Middle SDI 8 (6.54~9.53) 0.69 (0.56~0.84) 14.07 (12.02~17.64) 0.62 (0.52~0.77) −0.62 (−0.76~−0.48)
Low-middle SDI 4.64 (3.5~5.48) 0.66 (0.52~0.78) 9.19 (7.49~11.1) 0.67 (0.55~0.82) −0.06 (−0.13~0.01)
Low SDI 2.96 (1.83~4.07) 0.9 (0.55~1.38) 5.07 (3.72~6.61) 0.79 (0.55~1.06) −0.56 (−0.64~−0.48)
Region
East Asia 4.36 (2.73~5.34) 0.48 (0.31~0.58) 4.91 (3.75~5.83) 0.29 (0.21~0.34) −2.4 (−2.78~−2.02)
Southeast Asia 3.54 (2.83~4.91) 1.22 (0.97~1.69) 7.48 (6.03~10.35) 1.29 (1.04~1.76) 0 (−0.16~0.16)
Oceania 0.04 (0.02~0.06) 1.25 (0.78~2.25) 0.12 (0.08~0.16) 1.64 (1.13~2.26) 1.24 (1.11~1.37)
Central Asia 0.1 (0.08~0.13) 0.21 (0.16~0.27) 0.24 (0.2~0.32) 0.33 (0.28~0.44) 1.69 (1.44~1.94)
Central Europe 0.47 (0.41~0.69) 0.34 (0.3~0.5) 0.93 (0.56~1.14) 0.48 (0.28~0.59) 1.39 (1.15~1.63)
Eastern Europe 1.01 (0.77~1.83) 0.39 (0.3~0.7) 2.19 (1.59~2.64) 0.78 (0.56~0.95) 2.44 (2.05~2.83)
High-income Asia Pacific 1.37 (0.93~1.6) 0.79 (0.53~0.92) 4.42 (1.82~5.96) 0.75 (0.36~0.97) −0.69 (−1.09~−0.28)
Australasia 0.12 (0.1~0.18) 0.54 (0.46~0.79) 0.43 (0.2~0.56) 0.82 (0.39~1.04) 1.71 (1.38~2.04)
Western Europe 4.12 (3.15~7.55) 0.72 (0.56~1.3) 13.79 (6.58~17.12) 1.28 (0.63~1.57) 2.59 (2.15~3.03)
Southern Latin America 0.59 (0.41~0.75) 1.38 (0.94~1.77) 1.53 (1.18~1.8) 1.84 (1.42~2.16) 0.78 (0.48~1.07)
High-income North America 2.14 (1.63~3.84) 0.61 (0.46~1.08) 8.98 (4.33~11.04) 1.36 (0.68~1.65) 3.26 (2.43~4.09)
Caribbean 0.22 (0.18~0.29) 0.75 (0.65~0.97) 0.44 (0.35~0.54) 0.88 (0.71~1.08) 0.75 (0.69~0.81)
Andean Latin America 0.22 (0.16~0.28) 0.8 (0.59~0.94) 0.33 (0.25~0.43) 0.59 (0.44~0.76) −1.11 (−1.18~−1.03)
Central Latin America 0.43 (0.38~0.61) 0.4 (0.35~0.58) 1.29 (0.89~1.58) 0.54 (0.38~0.67) 1.15 (0.92~1.38)
Tropical Latin America 0.94 (0.8~1.47) 0.82 (0.7~1.35) 2.51 (1.77~2.82) 1.06 (0.74~1.19) 1.04 (0.78~1.3)
North Africa and Middle East 1.73 (1.25~2.12) 0.83 (0.64~0.99) 2.74 (2.07~3.29) 0.65 (0.51~0.79) −0.85 (−0.92~−0.78)
South Asia 3.79 (2.95~4.77) 0.64 (0.51~0.79) 8.77 (6.93~10.89) 0.64 (0.51~0.8) −0.12 (−0.2~−0.04)
Central Sub-Saharan Africa 0.32 (0.18~0.51) 1.17 (0.58~2.03) 0.61 (0.35~0.97) 1.02 (0.56~1.68) −0.58 (−0.65~−0.51)
Eastern Sub-Saharan Africa 1.13 (0.61~1.81) 1.14 (0.55~2.05) 1.83 (1.07~2.89) 0.91 (0.5~1.49) −0.9 (−1~−0.8)
Southern Sub-Saharan Africa 0.37 (0.25~0.44) 1.01 (0.7~1.2) 0.48 (0.39~0.61) 0.79 (0.65~1) −1.11 (−1.5~−0.71)
Western Sub-Saharan Africa 1.74 (0.91~2.45) 1.2 (0.73~1.76) 2.29 (1.76~3.05) 0.78 (0.61~1.02) −1.77 (−1.99~−1.55)

ASDR, age-standardized death rate per 100,000 population; SDI, social-demographic index; EAPC, estimated annual percentage change.