TABLE 3.
Distribution of germ-line mutations in breast cancer patients. Data has been stratified on the basis of age, hormone receptor status, and ethnicities.
| Sr No | Characteristic | Total carriers | Frequency of mutation carriers | ||
|---|---|---|---|---|---|
| Any Gene | BRCA1/2 | TP53 | |||
| 1 | Total patients with mutations | 10 | 0.12 (10/84) | 0.1 (08/84) | 0.03 (02/84) |
| 2 | Age at sampling (Agesamp) | ||||
| Agesamp ≤ 40 years | 6 | 0.15 (6/39) | 0.13 (5/39) | 0.03 (1/39) | |
| Agesamp > 40 years, positive FH | 4 | 0.08 (4/51) | 0.06 (3/51) | 0.02 (1/51) | |
| 3 | Tumour hormone receptors | ||||
| TNBC | 4 | 0.23 (4/17) | 0.23 (4/17) | 0 | |
| Non TNBC | 3 | 0.06 (3/49) | 0.02 (1/49) | 0.04 (2/49) | |
| Unknown | 3 | 0.3 | 0.2 | 0.1 | |
| 4 | Ethnicity | ||||
| Baloch | 0 | 0 | 0 | 0 | |
| Hindko | 2 | 0.5 (2/4) | 0.5 (2/4) | 0 | |
| Punjabi | 1 | 0.13 (1/8) | 0.13 (1/8) | 0 | |
| Pathan | 0 | 0 | 0 | 0 | |
| Sindhi | 2 | 0.11 (2/19) | 0.06 (1/19) | 0.06 (1/19) | |
| Urdu-Speaking | 3 | 0.15 (3/20) | 0.15 (3/20) | 0 | |
| Others | 0 | 0 | 0 | 0 | |
| Unknown | 2 | 0.18 (2/17) | 0.18 (2/17) | 0 | |