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. 2022 Mar 10;13:847444. doi: 10.3389/fneur.2022.847444

Table 1.

Results of subgroup analysis of BBB score (number of studies in brackets).

Species SCI models Source Transplant route Transplant dose WMD I 2
SD rats (27) Contusion (23) BMSCs-Exo (21) Tail veins (19) 100 μg (8) 1 week: 1.47 [0.30, 2.65]
2 weeks: 2.26 [1.04, 3.49]
3 weeks: 2.48 [0.27, 4.70]
4 weeks: 3.72 [1.81, 5.63]
24.0%
20.5%
26.6%
25.4%
SD rats (27) Contusion (23) BMSCs-Exo (21) Tail veins (19) 200 μg (11) 1 week: 1.76 [1.16, 2.36]
2 weeks: 2.98 [2.33, 3.63]
3 weeks: 3.74 [2.93, 4.56]
4 weeks: 4.36 [3.46, 5.26]
16.9%
18.3%
15.5%
13.9%
SD rats (27) Contusion (23) BMSCs-Exo (21) Subcutaneous (1)
SD rats (27) Contusion (23) BMSCs-Exo (21) Not reported (1)
SD rats (27) Contusion (23) NSCs-Exo (2) Tail veins (2) 20 μg (1)
SD rats (27) Contusion (23) NSCs-Exo (2) Tail veins (2) Not reported (1)
SD rats (27) Transection (3) BMSCs-Exo (2) Intranasal (1)
SD rats (27) Transection (3) BMSCs-Exo (2) Tail veins (1)
SD rats (27) Transection (3) HpMSC-Exo (1)
SD rats (27) Not reported (1)
C57BL/6 mice (3) Not reported (3)
Wistar rats (2) Hemi-sectioned (1)
Wistar rats (2) Contusion (1)