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. 2022 Mar 10;13:861525. doi: 10.3389/fimmu.2022.861525

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Copyright © 2022 Guo, Yang, Ren, Tian, Gao, Tian, Zhang and Kan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of immune score and functional enrichment analysis based on immune infiltration-related genes. (A) Alluvial plot of distribution of the ICI score and prognosis in different immune infiltration gene clusters. (B) Expression of immune checkpoint in high and low ICI score groups. ^* p < 0.05; ^** p < 0.01; ^*** p < 0.001; ns, not significant. (C, D) GO enrichment analysis of signature genes A (C) and B (D). (E, F) Gene set enrichment analysis (GSEA) of high score (E) and low score group (F). (G) Kaplan–Meier survival analysis of high score and low score groups divided based on the optimal cutoff value. (H) Kaplan–Meier survival analysis of high score and low score groups in the validation cohort (GSE10141).