TABLE 5.
Top 30 GO terms for the top 50 hub genes from the PPI networks of the host genes of the DE circRNAs.
| GO term | GO name | No. of genes | p-value |
|---|---|---|---|
| Biological process | |||
| GO:0,098,609 | cell-cell adhesion | 9 | 8.95E-07 |
| GO:0,030,198 | extracellular matrix organization | 7 | 1.91E-05 |
| GO:0,006,281 | DNA repair | 7 | 5.29E-05 |
| GO:0,007,067 | mitotic nuclear division | 7 | 7.13E-05 |
| GO:0,030,199 | collagen fibril organization | 4 | 1.86E-04 |
| GO:0,009,615 | response to virus | 5 | 2.72E-04 |
| GO:0,051,301 | cell division | 7 | 4.61E-04 |
| GO:0,030,574 | collagen catabolic process | 4 | 8.08E-04 |
| GO:0,007,051 | spindle organization | 3 | 9.36E-04 |
| GO:0,006,260 | DNA replication | 5 | 9.91E-04 |
| Molecular Function | |||
| GO:0,005,524 | ATP binding | 18 | 4.83E-07 |
| GO:0,098,641 | cadherin binding involved in cell-cell adhesion | 9 | 1.69E-06 |
| GO:0,005,515 | protein binding | 41 | 1.57E-05 |
| GO:0,048,407 | platelet-derived growth factor binding | 3 | 4.46E-04 |
| GO:0,005,201 | extracellular matrix structural constituent | 4 | 9.66E-04 |
| GO:0,003,677 | DNA binding | 13 | 0.002467 |
| GO:0,008,017 | microtubule binding | 5 | 0.003076 |
| GO:0,031,490 | chromatin DNA binding | 3 | 0.012302 |
| GO:0,003,725 | double-stranded RNA binding | 3 | 0.013545 |
| GO:0,003,777 | microtubule motor activity | 3 | 0.022588 |
| Cellular Component | |||
| GO:0,005,654 | nucleoplasm | 28 | 1.30E-10 |
| GO:0,030,496 | midbody | 8 | 5.07E-08 |
| GO:0,031,012 | extracellular matrix | 10 | 8.10E-08 |
| GO:0,005,913 | cell-cell adherens junction | 9 | 2.14E-06 |
| GO:0,005,829 | cytosol | 23 | 1.49E-05 |
| GO:0,005,634 | nucleus | 30 | 1.71E-05 |
| GO:0,072,686 | mitotic spindle | 4 | 1.81E-04 |
| GO:0,005,876 | spindle microtubule | 4 | 2.24E-04 |
| GO:0,005,737 | cytoplasm | 26 | 7.87E-04 |
| GO:0,005,604 | basement membrane | 4 | 0.001251 |