Table 4.
Current Available Inhibitors against MERS-CoV* and SARS-CoV.82
| Drug Classification | Drugs | Probable Mode of Action |
|---|---|---|
| Neurotransmitter inhibitor | Clomipramine HCl, chlorphenoxamine HCl, astemizole promethazine HCl, fluphenazine HCl, thiothixene, fluspirilene, benztropine mesylate | Clathrin-mediated endocytosis inhibitors |
| Antibiotic agent | Anisomycin | Protein processing inhibitor |
| Antibacterial agent | Emetine 2HCl·H2O, cycloheximide | Unknown protein synthesis inhibitor |
| Anticancer agents, antiparasitic agent/antimalarial | Dasatinib, imatinib, mesylate, chloroquine, 2H3PO4 mefloquine hydroxychloroquine SO4, amodiaquine 2HCl·H2O | Inhibition of viral replication |
| Estrogen receptor inhibitor | Toremifene citrate, tamoxifen citrate | Viral entry inhibitor |
| Nucleoside analog | Gemcitabine HCl | DNA metabolism inhibitor |
| Cytoskeleton inhibitors | Nocodazole | Microtubule depolymerization |
| Ion channel inhibitors | Monensin, salinomycin Na | Blocks the formation of virus particle and eruption |