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. 2022 Mar 10;13:809414. doi: 10.3389/fimmu.2022.809414

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Copyright © 2022 DePasquale, Ssozi, Ainciburu, Good, Noel, Villanueva, Couturier, Shalek, Aranki, Mallidi, Griffin, Lane and van Galen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exhaustion scores positively correlate with clone size in BPDCN samples. (A) Scatter plots show mean exhaustion score per cluster (x-axis) versus mean clone size (y-axis). Dots are scaled by the number of cells of each cluster in the dataset. (B) Violin plot shows T-cell exhaustion signature scores in CD8+ Memory T-cells in healthy controls (BM 1-5) and BPDCN samples with T-cells (BPDCN 1-4). (C–F) Box plots of cells binned by TCR clone size (x-axis) versus exhaustion score (y-axis) for T-cells in each BPDCN 1-4 sample as C-F. Parenthetical values on the x-axis labels indicate the normalized clone size.