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. 2022 Mar 10;12:849917. doi: 10.3389/fonc.2022.849917

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Copyright © 2022 Isabelle, Boles, Chakravarti, Porcu, Brammer and Mishra

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Contribution of critical cytokine signaling to large granular lymphocytic leukemia (LGLL) immunopathogenesis. Interleukin (IL)-15, platelet-derived growth factor (PDGF), IL-2, and IL-6 are all central players in the immunopathogenesis of LGLL. Dysregulation of these cytokines leads to constitutive activation of their downstream signaling pathways such as PI3K, JAK/STAT, Ras/MAPK, and NF-kB. This leads to increased transcription of oncogenic driver genes such as c-MYC, cyclin D1, and BCL-xL, ultimately leading to increased malignant cell proliferation and survival. Figure made with BioRender.com.