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. 2022 Mar 10;12:852859. doi: 10.3389/fonc.2022.852859

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Copyright © 2022 Vaughan, Kordich, Chan, Sasi, Celano, Sisson, Van Baren, Kortus, Aguiar, Martin and MacKeigan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular characterization of TSC cellular models. (A) Schematic for TSC2 protein structure in TSC2-deficient cell lines (621-102 and UMB1949) or 08-RA1 patient renal angiolipoma (RA) tumor; GAP, GTPase-activating protein. TSC2 deletion in patient-derived UMB1949 and renal angiomyolipoma 08-RA1. (B) Top 500 most differentially expressed genes (DEG), sorted high (top) to low (bottom) across the indicated samples and colored by log2 CPM according to the indicated scale. (C) The relative fraction of gene signatures estimated by CIBERSORT (gray, blood vessel; green, smooth muscle; orange, adipose; light blue, fetal kidney; dark blue, adult kidney; leukocytes purple).